2022
A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels
Hidden Markov Modeling with HMMTeacher
Nanoengineered Sprayable Therapy for Treating Myocardial Infarction
Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates
Evolution of the DAN gene family in vertebrates
2021
Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration
Molecular rotors as reporters for viscosity of solutions of collagen like peptides
Evolutionary history of the vertebrate Piwi gene family
The Critical Role of Oxidative Stress in Sarcopenic Obesity
Locus-specific analysis of Transposable Elements during the progression of ALS in the SOD1G93A mouse model
Whole-genome duplications and the diversification of the Globin-X Genes of vertebrates
Constitutive phosphorylation as a key regulator of TRPM8 channel function
Redox-Dependent Effects in the Physiopathological Role of Bile Acids
Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor
Molecular Pharmacology of K 2P Potassium Channels
Imaging the electrical activity of organelles in living cells
Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation
Odontoblast TRPC5 channels signal cold pain in teeth
Plant HKT Channels: An Updated View on Structure, Function and Gene Regulation
Effects of Interleukin-1β in Glycinergic Transmission at the Central Amygdala
Independent duplications of the Golgi phosphoprotein 3 oncogene in birds
Studying ion channel conformation dynamics by encoding coumarin as unnatural amino acid
TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer
TMPRSS11a is a novel age-altered, tissue specific regulator of migration and wound healing
5-(Indol-2-yl)pyrazolo[3,4- b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis
Cellular response of human apical papilla cells to calcium hydroxide and tricalcium silicate-based cements
PPI-MASS: An Interactive Web Server to Identify Protein-Protein Interactions From Mass Spectrometry-Based Proteomics Data
Cobalt ions induce metabolic stress in synovial fibroblasts and secretion of cytokines/chemokines that may be diagnostic markers for adverse local tissue reactions to hip implants
Diversity of functional alterations of the ClC-5 exchanger in the region of the proton glutamate in patients with Dent disease 1
Identification of a critical binding site for local anaesthetics in the side pockets of K v 1 channels
Positive selection and gene duplications in tumour suppressor genes reveal clues about how cetaceans resist cancer
Impact of exercise training on the sarcopenia criteria in non-alcoholic fatty liver disease: a systematic review and meta-analysis
GSER (a Genome Size Estimator using R): a pipeline for quality assessment of sequenced genome libraries through genome size estimation
2020
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca 2+ transfer for survival
TRPM Channels in Human Diseases
Gating and calcium-sensing mechanisms of TRPA1 channels revealed
Voltage-Gated K +/Na + Channels and Scorpion Venom Toxins in Cancer
Gabapentin Inhibits Multiple Steps in the Amyloid Beta Toxicity Cascade
TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death
A rationally designed orthogonal synthetase for genetically encoded fluorescent amino acids
SARS-CoV-2/Renin-Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle
Angiotensin (1-7) Decreases Myostatin-Induced NF-κB Signaling and Skeletal Muscle Atrophy
The Globin Gene Family in Arthropods: Evolution and Functional Diversity
Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD)
Structural Determinants of the Dopamine Transporter Regulation Mediated by G Proteins
Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing
Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle
Ca v 1.2 Activity and Downstream Signaling Pathways in the Hippocampus of An Animal Model of Depression
Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K 2 P Channels
Protective Effect of Angiotensin 1-7 on Sarcopenia Induced by Chronic Liver Disease in Mice
Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons
A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles
MicroRNAs from Extracellular Vesicles Secreted by Bovine Embryos as Early Biomarkers of Developmental Competence
Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels
Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer’s disease
KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis
Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor
Effect of sevoflurane and propofol on tourniquet-induced endothelial damage: a pilot randomized controlled trial for knee-ligament surgery
Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia
Zinc binding promotes greater hydrophobicity in Alzheimer’s Aβ42 peptide than copper binding: Molecular dynamics and solvation thermodynamics studies
Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5
Does Peer Reviewing for COVID-19-Related Papers Still Work?
K + Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca 2+ Signaling and Rac1 Activity
Correction: OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells
New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative
2019
TASK Channels Pharmacology: New Challenges in Drug Design
Chalcone derivatives as non-canonical ligands of TRPV1
Light-Activated Peptide-Based Materials for Sutureless Wound Closure
Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states
Potential Novel Strategies for the Treatment of Dental Pulp-Derived Pain: Pharmacological Approaches and Beyond
Thermodynamics of Adsorption on Graphenic Surfaces from Aqueous Solution
Calcium-dependent inactivation controls cardiac L-type Ca 2+ currents under β-adrenergic stimulation
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia
Complex I and II are required for normal mitochondrial Ca 2+ homeostasis
An extracellular cation coordination site influences ion conduction of OsHKT2;2
The molecular basis for an allosteric inhibition of K +-flux gating in K 2P channels
A Structural Model of the Inactivation Gate of Voltage-Activated Potassium Channels
A pharmacological master key mechanism that unlocks the selectivity filter gate in K + channels
Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine
Endothelial Cells Exhibit Two Waves of P-selectin Surface Aggregation Under Endotoxic and Oxidative Conditions
EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion
Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials
CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+ T Cells in a Neuropilin-1-Dependent Manner
Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway
Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage
OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells
Yeast strain Saccharomyces cerevisiae BYT45 lacking the cation extrusion systems ENA1-5 and NHA1 is suitable for the characterization of TASK-3 potassium channel antagonists
Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation
New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative
Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: a New Target for Sepsis
TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines
Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site
2018
Non-invasive Neurite Mechanics in Differentiated PC12 Cells
Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration
Experimental and Computational Characterization of the Interaction between Gold Nanoparticles and Polyamidoamine Dendrimers
Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A
Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3
Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity
In silico analysis of the competition between Streptococcus sanguinis and Streptococcus mutans in the dental biofilm
Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury
Myeloid CD11c + Antigen-Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II Plus High-Salt Diet
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway
Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison
2017
Computational Studies of Snake Venom Toxins
IKD Current in Cold Transduction and Damage-Triggered Cold Hypersensitivity
Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca V) Channels
Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1
The IKD current in cold detection and pathological cold pain
Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration
Prolonged AT 1 R activation induces Ca V 1.2 channel internalization in rat cardiomyocytes
TRPM4 activation by chemically- and oxygen deprivation-induced ischemia and reperfusion triggers neuronal death
KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence
Mineralocorticoids modulate the expression of the β-3 subunit of the Na +, K +-ATPase in the renal collecting duct
Aged blood factors decrease cellular responses associated with delayed gingival wound repair
Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid