Publicaciones

Publicaciones

2022

A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels

Hidden Markov Modeling with HMMTeacher

Nanoengineered Sprayable Therapy for Treating Myocardial Infarction

Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates

Evolution of the DAN gene family in vertebrates

2021

Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration

Molecular rotors as reporters for viscosity of solutions of collagen like peptides

Evolutionary history of the vertebrate Piwi gene family

The Critical Role of Oxidative Stress in Sarcopenic Obesity

Locus-specific analysis of Transposable Elements during the progression of ALS in the SOD1G93A mouse model

Whole-genome duplications and the diversification of the Globin-X Genes of vertebrates

Constitutive phosphorylation as a key regulator of TRPM8 channel function

Redox-Dependent Effects in the Physiopathological Role of Bile Acids

Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor

Molecular Pharmacology of K 2P Potassium Channels

Imaging the electrical activity of organelles in living cells

Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation

Odontoblast TRPC5 channels signal cold pain in teeth

Plant HKT Channels: An Updated View on Structure, Function and Gene Regulation

Effects of Interleukin-1β in Glycinergic Transmission at the Central Amygdala

Independent duplications of the Golgi phosphoprotein 3 oncogene in birds

Studying ion channel conformation dynamics by encoding coumarin as unnatural amino acid

TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer

TMPRSS11a is a novel age-altered, tissue specific regulator of migration and wound healing

5-(Indol-2-yl)pyrazolo[3,4- b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis

Cellular response of human apical papilla cells to calcium hydroxide and tricalcium silicate-based cements

PPI-MASS: An Interactive Web Server to Identify Protein-Protein Interactions From Mass Spectrometry-Based Proteomics Data

Cobalt ions induce metabolic stress in synovial fibroblasts and secretion of cytokines/chemokines that may be diagnostic markers for adverse local tissue reactions to hip implants

Diversity of functional alterations of the ClC-5 exchanger in the region of the proton glutamate in patients with Dent disease 1

Identification of a critical binding site for local anaesthetics in the side pockets of K v 1 channels

Positive selection and gene duplications in tumour suppressor genes reveal clues about how cetaceans resist cancer

Impact of exercise training on the sarcopenia criteria in non-alcoholic fatty liver disease: a systematic review and meta-analysis

GSER (a Genome Size Estimator using R): a pipeline for quality assessment of sequenced genome libraries through genome size estimation

2020

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca 2+ transfer for survival

TRPM Channels in Human Diseases

Gating and calcium-sensing mechanisms of TRPA1 channels revealed

Voltage-Gated K +/Na + Channels and Scorpion Venom Toxins in Cancer

Gabapentin Inhibits Multiple Steps in the Amyloid Beta Toxicity Cascade

TRP Channels Regulation of Rho GTPases in Brain Context and Diseases

TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death

A rationally designed orthogonal synthetase for genetically encoded fluorescent amino acids

SARS-CoV-2/Renin-Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle

Angiotensin (1-7) Decreases Myostatin-Induced NF-κB Signaling and Skeletal Muscle Atrophy

The Globin Gene Family in Arthropods: Evolution and Functional Diversity

Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD)

Structural Determinants of the Dopamine Transporter Regulation Mediated by G Proteins

Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing

Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle

Ca v 1.2 Activity and Downstream Signaling Pathways in the Hippocampus of An Animal Model of Depression

Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K 2 P Channels

Protective Effect of Angiotensin 1-7 on Sarcopenia Induced by Chronic Liver Disease in Mice

Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons

A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles

MicroRNAs from Extracellular Vesicles Secreted by Bovine Embryos as Early Biomarkers of Developmental Competence

Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels

Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer’s disease

KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis

Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor

Effect of sevoflurane and propofol on tourniquet-induced endothelial damage: a pilot randomized controlled trial for knee-ligament surgery

Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3

TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia

Zinc binding promotes greater hydrophobicity in Alzheimer’s Aβ42 peptide than copper binding: Molecular dynamics and solvation thermodynamics studies

Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5

Does Peer Reviewing for COVID-19-Related Papers Still Work?

K + Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca 2+ Signaling and Rac1 Activity

Correction: OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells

New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative

2019

TASK Channels Pharmacology: New Challenges in Drug Design

Chalcone derivatives as non-canonical ligands of TRPV1

Light-Activated Peptide-Based Materials for Sutureless Wound Closure

Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states

Potential Novel Strategies for the Treatment of Dental Pulp-Derived Pain: Pharmacological Approaches and Beyond

Thermodynamics of Adsorption on Graphenic Surfaces from Aqueous Solution

Calcium-dependent inactivation controls cardiac L-type Ca 2+ currents under β-adrenergic stimulation

TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia

Complex I and II are required for normal mitochondrial Ca 2+ homeostasis

An extracellular cation coordination site influences ion conduction of OsHKT2;2

The molecular basis for an allosteric inhibition of K +-flux gating in K 2P channels

A Structural Model of the Inactivation Gate of Voltage-Activated Potassium Channels

A pharmacological master key mechanism that unlocks the selectivity filter gate in K + channels

Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening

Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine

Endothelial Cells Exhibit Two Waves of P-selectin Surface Aggregation Under Endotoxic and Oxidative Conditions

EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion

Nanoparticle Concentration vs Surface Area in the Interaction of Thiol-Containing Molecules: Toward a Rational Nanoarchitectural Design of Hybrid Materials

CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+ T Cells in a Neuropilin-1-Dependent Manner

Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway

Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage

OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells

Yeast strain Saccharomyces cerevisiae BYT45 lacking the cation extrusion systems ENA1-5 and NHA1 is suitable for the characterization of TASK-3 potassium channel antagonists

Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation

New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative

Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: a New Target for Sepsis

TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines

Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site

2018

Non-invasive Neurite Mechanics in Differentiated PC12 Cells

Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration

Experimental and Computational Characterization of the Interaction between Gold Nanoparticles and Polyamidoamine Dendrimers

Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A

Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3

Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity

In silico analysis of the competition between Streptococcus sanguinis and Streptococcus mutans in the dental biofilm

Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury

Myeloid CD11c + Antigen-Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II Plus High-Salt Diet

FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway

Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison

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